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KMID : 0374920080290010173
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Inje Medical Journal
2008 Volume.29 No. 1 p.173 ~ p.182
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A Case of Hepatotoxicity after Alchol Splanchnic Neurolytic Block in a Patient with Pancreatic Head Cancer
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Lee Sang-Eun
Choi Suk-Whan
Kim Young-Hwan
Lim Se-Hun
Lee Jeong-Han
Lee Kun-Moo
Cheong Soon-Ho
Choe Young-Kyun
Kim Young-Jae
Shin Chee-Mahn
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Abstract
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Splanchnic neurolytic block(SNB) with alcohol improves the management of pancreatic cancer pain. Adverse effects of alcohol SNB which include regional pain, hypotension, diarrhea, and acute alcohol intoxication are common, but acute hepatitis caused by alcohol neurolytic block is rare. A 63-year-old patient with pancreatic head cancer and liver metastasis had complete pain relief after both retrocrural tansdiscal SNB with 100% alcohol 10 ml. But, 1 day later, liver function test showed a high elevation in the aspartate aminotransferase (AST, 2182 IU/L) and alanine aminotransferase (ALT, 1807 IU/L). The patient had slight jaundice, general weakness, chilling, nausea and vomiting after SNB. Both AST and ALT decreased to 46 and 119 IU/L within 10 days with only supportive therapy. But, 19 days later, the patient died due to pneumonia. Our case illustrates the importance of clinical surveillance especially in patient with hepatic disease after alcohol SNB.
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KEYWORD
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alcohol, hepatitis, splanchnic neurolytic block
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